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Part of the Vasobral (Vazobral) alpha dihydroergocriptine - dihydrogenated ergot derivative - blocks alpha 1 and alpha 2-adrenergic receptors of vascular smooth muscle cells. It has a stimulating effect on the dopamine and serotonin receptors of the central nervous system.
In applying the drug decreases platelet aggregation and red blood cells, decreased vascular permeability, improving blood circulation and metabolic processes in the brain, increases resistance to brain tissue hypoxia.
Caffeine has a stimulating effect on the central nervous system, mainly in the cerebral cortex, respiratory and vasomotor centers. It improves mental and physical performance, reduces fatigue.
Vasobral - drug combination (Dihydroergocryptine + Caffeine). Its active ingredients are such that stimulate the central nervous system receptors, resulting in an improvement of blood circulation and metabolism in the brain. The components of the drug causing a reduction in platelet adhesion and red blood cells, and decreased permeability of the blood vessel walls. Increased stability of brain tissue to hypoxia (lack of oxygen due to poor supply to the brain, or by reason of breach of oxygen uptake by the brain). The prophylactic effect of the drug Vasobral with persistent migraine proven clinically. Caffeine, which is part of the preparation Vazobral, has psychoactive and analeptic action. Ergot alkaloids, which is part of the drug blocks the adrenergic receptors of vascular smooth muscle walls that reduced vascular tone. A block vasoconstrictor effect at high vascular tone.
When taken orally, the absorption dihydroergocriptine accelerated in the presence of caffeine (time to maximum concentration of 0.5 hours).
The maximum concentration after oral administration of 8 mg of a-dihydroergocriptine 227 pg / ml and the half life time - less than 2 hours.
Hypersensitivity to the drug; pregnancy; lactation.
Vasobral has a vasodilatory effect, without affecting systemic blood pressure. Appointment Vazobral hypertensive patients does not exclude the need for the use of antihypertensive drugs. Contained in the preparation of caffeine can cause sleep disturbance, tachycardia.
Inside (during meals, with a small amount of liquid) to 1 \ 2 tablet 2-1 times a day. The duration of treatment 2-3 months, 1-2 times a year can be carried out if necessary treatments.
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