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Hypnotic Donormyl (Donormil) contains an active substance which is a blocker of class ethanolamines histamine H1-receptor. Sleeping pills reduce the time to fall asleep and increases the duration of sleep. Duration of action - up to 8 hours. The maximum plasma concentration is reached after 1 hour after use, and plasma half-life averages 10 hours. 60% is excreted through the kidneys in unchanged form, part of the drug is excreted through the digestive tract.
Alcohol increases the sedative effect of the drug Donormyl, therefore not recommended to use this medication along with alcohol and drugs. In applying the drug with alcohol, doctors reviews the following: even in small doses, alcohol can enhance the effect of the drug, resulting in an overdose.
At the same time taking the drug Donormyl with sedative antidepressants (amitriptyline, doxepin, mianserin, mirtazapine, trimipramine), barbiturates, benzodiazepines, clonidine, morphine derivatives (analgesics, antitussive agents), antipsychotics, anxiolytics, sedative antihistamines, central antihypertensives, thalidomide, baclofen , pizotifenom dampening effect on the central nervous system.
In simultaneous reception with m-anticholinergic agents (atropine, imipraminovye antidepressants, anti-Parkinsonian drugs atropinovye antispasmodics, disopyramide, phenothiazine neuroleptics) increases the risk of side effects such as urinary retention, constipation, dry mouth.
Because ethanol enhances sedation most antagonists of H1-histamine receptors, including Donormyl and preparation, it is necessary to avoid simultaneous use with alcoholic beverages and drugs containing ethanol.
Inside. At 1/2 - 1 tablet. a day with a small amount of liquid, 15-30 minutes before bedtime.
If the treatment is ineffective, on doctor's advice dose may be increased to 2 tablets.
Duration of treatment - from 2 to 5 days; If insomnia persists, seek medical advice.
Special patient groups
Patients with renal failure and kidney. In connection with the data to increase the concentration in plasma and the plasma clearance decreases doxilamine recommended dosage adjustment downwards.
Patients older than 65 years. Blockers H1-histamine receptors should be used with caution in this group of patients because of dizziness and a delayed reaction to the danger of falling (eg at nighttime awakenings after receiving hypnotics). recommended dose correction downward view of the rising concentration in the plasma, the plasma clearance decreases and increase half-life.
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