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Paxil - instructions, dosage, side effects, analogs

06 Aug 2019

Antidepressant: Paxil

Active ingredient: Paroxetine (paroxetine)

Analogs: Rexetin - Gedeon Richter (Hungary), Adepress - Veropharm (Russia), Aktaparoxetine - Aktavis (Iceland), Plizil - Pliva (Croatia), Paroxetine hydrochloride hemihydrate, Sirestill - Italfarmaco (Italy)

"Paxil" refers to the antidepressants of the SSRIs group (Selective serotonin reuptake inhibitors). Thus, his work is based on selective blocking of the absorption of serotonin by the membrane of the presynaptic cell. As a result, the concentration of this neurotransmitter in the synaptic cleft is significantly increased, which in turn exerts a pronounced antidepressant effect.

In this case, the substance that forms the basis of the drug (paroxetine) does not interfere in the work of the cardiovascular system, does not exert a depressing effect on the central nervous system and does not affect the psychomotor functions. Paxil does not provoke changes in both blood pressure and palpitations, as well as electrical activity of the brain (provided that the patient taking the drug does not have health problems with the above systems of organs). Paxil (paroxetine) is not able to cause sleep disturbances during its morning reception. On the contrary, with regular administration of the drug, there is an improvement in the quality of sleep.

Psychotrophic activity of Paxil is expressed in a tangible antidepressant and anti-anxiety action. When it is used in doses that are more than necessary for blocking the reuptake of serotonin, there may appear minor activating effects. In general, the effectiveness of this drug in the treatment of depressive conditions almost reaches the effectiveness of tricyclic antidepressants. In addition, Paxil causes an improvement in the condition of patients who have not been helped by standard antidepressant therapy. Positive changes occur already during the first week of application. Over the next few weeks, the state of patients with depression and suicidal tendencies improves dramatically. Observation of people taking Paxil during the year showed that the drug perfectly protects against recurrence of depression. Outstanding results demonstrate the use of paroxetine for the treatment of patients with panic disorder in combination with drugs that normalize cognitive function: this approach proved to be much more effective than monotherapy with drugs that correct cognitive behavioral function.

Indications for use:

- Any depression, including depression, reactive, severe endogenous depression and depression in combination with anxiety disorders;
- therapy, prevention and treatment of obsessive-compulsive disorder in children and adolescents 7-17 years old, and in adults. In this case, patients who took Paxil for a year or more are practically not affected by recurrence of OCD. The drug retains its effects even with such a long period of use;
therapy, prevention and treatment of panic disorder (including agoraphobia). Paxil retains its effectiveness and prevents the recurrence of the disorder;
- therapy, prevention and treatment of social phobia in children and adolescents 7 - 17 years, and adults. The effectiveness of paroxetine in the treatment of this phobia does not weaken throughout the year;
- therapy, prevention and treatment of generalized anxiety disorder. In this case, Paxil also prevents the return of the disorder, and its effectiveness does not decrease within a year;
- treatment of post-traumatic stress;

Contraindications: Paxil should not be taken concomitantly with the use of MAO inhibitors. The time between paroxetine and MAO should be at least 2 weeks. The simultaneous use of thioridazine is also prohibited. In addition, one should pay attention to the individual sensitivity to the components of the antidepressant (with hypersensitivity it is necessary to abandon its use).

Dosing and Administration: In the treatment of depression in adults, the standard therapeutic dose is 20 mg per day. However, if Paxil has insufficient influence on the patient's condition, it is possible to increase the dosage to the maximum of 50 mg per day. Do not dramatically increase the dose, it is recommended to gradually add 10 mg every week. Increase the dosage is recommended after 2-3 weeks after the start of the drug.

In the treatment of obsessive-compulsive syndrome, it is necessary to start taking the drug in an amount of 20 mg per day. Then add 10 mg every week. After reaching 40 mg / day, it is necessary to suspend the increase in dosage. If the desired effect can not be achieved, it is possible to increase the dose to 60 mg / day. For children aged 7 to 17 years, the daily dose can be increased from 10 mg per day to 50 mg.

In the treatment of panic disorder in adults, the average dosage is 40 mg / day. In order to avoid a possible exacerbation of the symptoms of the disorder, it is necessary to start the dose size of the drug from 10 mg / day. A weekly dose increase of 10 mg should be stopped when the effect is achieved. The maximum possible dosage is 60 mg per day.

With social phobia, the dosage for an adult begins at 20 mg / day, the child (8 - 17 years) with 10 mg / day. Dosage should be increased by 10 mg every week and stop the increase in the event that the drug will produce a tangible positive effect. The maximum dose for both adults and children is 50 mg per day.

In generalized anxiety disorder in adults, the maximum dose is 50 mg / day, the average dose is 20 mg.For the removal of post-traumatic stress disorder in adults, a dosage of 20 mg / day is recommended, which can be gradually increased to 50 mg. Older patients should start using Paxil from an average adult dose. The upper dosage limit should not exceed 40 mg / day. Patients with kidney and liver disease should not increase the dosage above the minimum.

In the treatment of depression, the course of taking the drug may last several months, while treating obsessive-compulsive disorder - even longer. "Paxil" must be consumed until all symptoms disappear completely. Antidepressant should be taken once a day during the first half of the day during meals. The medicine should be washed down with water, swallowing the tablets without chewing.

Discontinuation of use: Discontinue use of the drug should be gradual. It is required to reduce the dosage by 10 mg weekly until the amount of the drug taken reaches 20 mg / day for adults and 10 mg / day for children. After this, take Paxil within one week, and then completely stop using it. If withdrawal symptoms appear, resume taking the initial dose of the drug, then try a slower rate of dosage reduction.

Side effects: The most frequent side effects of the drug Paxil (paroxetine): decreased appetite, nausea, dry mouth, constipation, dizziness, drowsiness, yawning, increased sweating, occur in a small percentage of patients; in clinical trials, side effects were found in about 6 % of subjects

Storage conditions: Paxil must be stored at a temperature not exceeding 30 C in a place inaccessible to children.
Attention, this page is only informational in nature, before consulting with the antidepressant "Paxil" (paroxetine), consult a physician.

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