Trittico - instructions, dosage, side effects, analogs
Antidepressant: Trittico (Trittico)
Active ingredient: Trazodone (trazodone)
Trittico (trazodone) is an antidepressant that does not belong to any of the groups of these drugs. Has a wide spectrum of action, which includes anxiolytic, timoleptic, muscle relaxant and sedative effect. Slightly affects the re-uptake of dopamine and norepinephrine, mainly acting on the reuptake of serotonin. By the degree of effectiveness this drug is comparable with tricyclic antidepressants, significantly exceeding them in terms of safety and less pronounced side effect.
Trittico (trazodone) successfully fights with such manifestations of anxiety as fear, tension, insomnia and irritability, as well as somatic manifestations, such as headache, palpitation, myalgia, frequent urination and increased sweating. The drug positively affects the sleep, normalizing its physiological structure, which manifests itself in an increase in the duration, as well as the depth of sleep. The drug promotes the return of sexual desire and potency, reduces cravings for ethanol, and is also effectively used in the treatment of patients with an abstinence syndrome (with drug dependence on benzodiazepines).
In this case, the drug is characterized by a high level of safety, does not inhibit MAO, does not cause dependence, does not give an anticholinergic effect, and also in no way contributes to a change in body weight. In half of patients, the therapeutic effect is observed after 3-7 days of trazodone (this is especially true for sleep stabilization and anxiety relief), in 25% for 2-4 weeks.
Especially effective is "trittico" in the treatment of depressions, accompanied by disturbances in night sleep. About 67% of patients taking "trittico" noted improvement in the quality of sleep, its strength, and also got rid of nocturnal awakenings, in contrast to 13% of subjects who took a placebo. In addition, the drug has proven itself in the fight against insomnia caused by other antidepressants.
Indications for use:
- depression of the most diverse etiology: neurotic, endogenous, somatogenic, psychotic, including with accompanying increased anxiety. The reason for taking the drug is sufficient if the depression has at least 4 symptoms from the following: psychomotor inhibition or agitation, sleep and appetite disorders, decreased interest in life, lack of sexual interest, slow thinking, fatigue, guilt, suicidal tendencies, and a decrease concentration of attention;
- various phobias;
- drug dependence on benzodiazepines;
- acute withdrawal syndrome;
- impotence / decreased libido;
- prevention of migraines.
Contraindications: Trazodone should not be taken with increased sensitivity to this substance, during pregnancy and lactation, patients with ventricular arrhythmia, priapism in the anamnesis, tachycardia, and also in the early recovery period of myocardial infarction.
Dosage and administration: Trazodone taken internally. Adults should start with a daily dosage of 150 mg in two divided doses. The first dose is 2/3 of the entire dose and taken before bedtime to avoid dizziness and drowsiness, and the remainder is taken in the morning or throughout the day. If the effect is insufficient, the dose may be increased by 50 mg / day every 3-4 days. The maximum dose is 450 mg / day for outpatients and 600 mg / day for inpatients.
The maintenance dose for mild forms of depression is 150 mg / day, at heavy - 300 mg / day.
For the elderly, as well as weakened patients, it is necessary to lower the initial dose in half. If necessary, it can be gradually increased to 300 mg with an interval of 3-4 days.
Children 6-18 should take trazodone at a rate of 1.5-2 mg per 1 kg of body weight per day (the doses should be divided). To achieve the optimum effect, the dosage can be increased to 6 mg / 1 kg of body weight per day.
To normalize the libido, you should take 50 mg of trazodone per day. With complex therapy of impotence, the dosage is also 50 mg / day, with monotherapy - 200 mg / day.
In the treatment of benzodiazepine dependence, its main principle is a gradual decrease in the benzodiazepine administered. With each reduction of its dosage at? or ? Tablets should increase the daily dose of trazodone by 50 mg. Dosage remains unchanged for three weeks, then it should continue to gradually reduce the dose of benzodiazepine until the drug is completely abandoned. After this, the dosage of trazodone should be gradually reduced (by 50 mg every three weeks).
Side effects: The most frequent of them: fatigue, dizziness, nervous state, headache, arrhythmia, insomnia, nausea, vomiting, lowering of blood pressure, dryness and bitterness in the mouth, diarrhea, nasal congestion, and allergic reactions.
Terms of selling from the pharmacy: The drug is released on prescription.